Mcl-1 inhibitor 19

Mcl-1 inhibitor 19

• UNSPSC Description: Mcl-1 inhibitor 19 (compound 26) binds to Mcl-1, with the Ki of 86 pM. Mcl-1 inhibitor 19 inhibits growth in H929 cells with the GI of 43 nM[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mcl-1-inhibitor-19.html
• Smiles: ClC1=CC=C(C2=C1C3=C(N=C(N=C3C)C)C)C(CCCOC4=CC(C)=C(C(C)=C4)Cl)=C5N2[C@@H](CN(C5=O)C6=CC(OCC7CCOCC7)=C(C8=C6N(C(C(O)=O)=C8)C)OC)C
• Molecular Weight: 868.84
• References & Citations: [1]James C Tarr, et al. Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. J Med Chem. 2024 Aug 22;67(16):14370-14393.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported