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2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

CAT:
804-HY-W141392
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite - image 1

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

  • CAS Number: 2245842-16-2
  • UNSPSC Description: 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
  • Target Antigen: Nucleoside Antimetabolite/Analog
  • Type: Reference compound
  • Related Pathways: Cell Cycle/DNA Damage
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/2-fluoro-5-o-dmt-2-deoxyinosine-3-ce-phosphoramidite.html
  • Purity: 98.81
  • Solubility: 10 mM in DMSO
  • Smiles: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C(NC=NC6=O)=C6N=C5)O4
  • Molecular Weight: 772.80
  • References & Citations: [1]Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.
  • Shipping Conditions: Room Temperature
  • Storage Conditions: 4°C (Powder, stored under nitrogen)
  • Clinical Information: No Development Reported

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