IKZF3 Polyclonal Antibody

IKZF3 Polyclonal Antibody

• Background: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
• Synonyms: IKZF3,AIO,AIOLOS,ZNFN1A3
• CAS Number: 9007-83-4
• Gene ID: 22806
• Swiss Prot: Q9UKT9
• Host: Rabbit
• Reactivity: Human,Mouse
• Immunogen: Recombinant fusion protein of human IKZF3 (NP_036613.2).
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: IF
• Purification: Affinity purification
• Concentration: 1 mg/mL
• Dilution: IF 1:50-1:100
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.