DOK4 Polyclonal Antibody
CAT:
866-RD75550A-03
Size:
120 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DOK4 Polyclonal Antibody
- Background: Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
- Synonyms: docking protein 4,Downstream of tyrosine kinase 4,FLJ10488,insulin receptor substrate 5,IRS5
- CAS Number: 9007-83-4
- Swiss Prot: Q8TEW6
- Accession Number: BC001540
- Host: Rabbit
- Reactivity: Human,Mouse
- Immunogen: Recombinant protein of human DOK4
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: IHC,ELISA
- Purification: Affinity purification
- Concentration: 0.5 mg/mL
- Dilution: IHC 1:50-1:200
- Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
- Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.