DOK4 Polyclonal Antibody

• Background:

  Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

• Synonyms:

  docking protein 4,Downstream of tyrosine kinase 4,FLJ10488,insulin receptor substrate 5,IRS5

• CAS Number:

  9007-83-4

• Swiss Prot:

  Q8TEW6

• Accession Number:

  BC001540

• Host:

  Rabbit

• Reactivity:

  Human,Mouse

• Immunogen:

  Recombinant protein of human DOK4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Applications:

  IHC,ELISA

• Purification:

  Affinity purification

• Concentration:

  0.5 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.