Anti-CDK4 Antibody
CAT:
519-M00159-2
Size:
200 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-CDK4 Antibody
- Background: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Description: Boster Bio Anti-CDK4 Antibody (Catalog # M00159-2). Tested in WB, IHC-P application(s). This antibody reacts with Human, Mouse.
- Synonyms: Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
- Gene Name: CDK4
- UniProt: P11802
- Host: Mouse
- Reactivity: Human, Mouse
- Immunogen: This CDK4 antibody is generated from a mouse immunized with a recombinant protein.
- Clonality: Monoclonal
- Applications: WB, IHC-P
- Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
- Molecular Weight: 33730 Da
- Components: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
- Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Fragment: IgG2a, κ
- Clone ID: Clone: 1529CT850.162.73