IGF-BP5 Recombinant Protein
CAT:
209-100-201S
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IGF-BP5 Recombinant Protein
- Description: IGF-BP5 is a member of the insulin-like growth factor binding protein (IGF-BP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
- Synonyms: IGFBP5; IBP5
- CAS Number: 9000-83-3
- NCBI Gene ID: 3488
- UniProt: P24593
- Accession Number: NP_000590.1
- Accession Number mRNA: NM_000599
- Gene Location: 2q33-q36
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Human
- Sequence: MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS
- Detection Range: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 253
- Form: Lyophilized
- Molecular Weight: 28.6 kDa
- Shipping Conditions: Room Temperature