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IGF-BP1 Recombinant Protein

CAT:
209-100-197S
Size:
5 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
IGF-BP1 Recombinant Protein - image 1

IGF-BP1 Recombinant Protein

  • Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).
  • Synonyms: IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
  • CAS Number: 9000-83-3
  • NCBI Gene ID: 3484
  • UniProt: P08833
  • Accession Number: NP_000587.1
  • Accession Number mRNA: NM_000596.2
  • Gene Location: 7p13-p12
  • Host: E. coli
  • Origin Species: Human
  • Species Reactivity: Human
  • Sequence: MAPWQCAPCS AEKLALCPPV SASCSEVTRS AGCGCCPMCA LPLGAACGVA TARCARGLSC RALPGEQQPL HALTRGQGAC VQESDASAPH AAEAGSPESP ESTEITEEEL LDNFHLMAPS EEDHSILWDA ISTYDGSKAL HVTNIKKWKE PCRIELYRVV ESLAKAQETS GEEISKFYLP NCNKNGFYHS RQCETSMDGE AGLCWCVYPW NGKRIPGSPE IRGDPNCQIY FNVQN
  • Detection Range: The ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is ≤ 0.5 μg/ml in the presence of 6 ng/ml of human IGF-I.
  • Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
  • Purity: > 98% by SDS-PAGE & HPLC analyses
  • Length: 235
  • Form: Lyophilized
  • Molecular Weight: 25.4 kDa
  • Shipping Conditions: Room Temperature