EGFR mutant-IN-2
CAT:
804-HY-155005-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR mutant-IN-2
- CAS Number: 2770009-06-6
- UNSPSC Description: EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].
- Target Antigen: EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-mutant-in-2.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: FC(F)(F)C1=CN=C(NC2=CC(C=CN3CCN(C)C)=C3C=C2)N=C1C4=CN(S(CC)(=O)=O)C5=C4C=CC=C5
- Molecular Weight: 556.60
- References & Citations: [1]Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66(10):6849-6868.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported