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Lobeline (hydrochloride)

CAT:
804-HY-B0979-01
Size:
5 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Lobeline (hydrochloride) - image 1

Lobeline (hydrochloride)

  • CAS Number: 134-63-4
  • UNSPSC Description: Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation[1][2].
  • Target Antigen: Dopamine Transporter; nAChR
  • Type: Natural Products
  • Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
  • Applications: Neuroscience-Neuromodulation
  • Field of Research: Neurological Disease
  • Assay Protocol: https://www.medchemexpress.com/Lobeline-hydrochloride.html
  • Purity: 99.98
  • Solubility: H2O : 6 mg/mL (ultrasonic)
  • Smiles: CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl
  • Molecular Weight: 373.92
  • References & Citations: [1]Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. |[2]Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70.|[3]Harrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298(1):172-9.
  • Shipping Conditions: Room Temperature
  • Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
  • Clinical Information: Launched