Delavirdine

Delavirdine

• CAS Number: 136817-59-9
• UNSPSC Description: Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1].
• Target Antigen: HIV; Reverse Transcriptase
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/delavirdine.html
• Purity: 99.60
• Solubility: DMSO : 17.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=S(NC1=CC=C(NC(C(N2CCN(C3=C(NC(C)C)C=CC=N3)CC2)=O)=C4)C4=C1)(C)=O
• Molecular Weight: 456.56
• References & Citations: [1]Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.|[2]Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research ArticleSci Rep. 2015 Oct 29;5:15806.|Future Med Chem. 2018 Dec 17. |Int J Antimicrob Agents. 2019 Dec;54(6):814-819.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched