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CD40L/CD154/TRAP, Rabbit (His)

CAT:
804-HY-P72122-01
Size:
5 µg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
CD40L/CD154/TRAP, Rabbit (His) - image 1

CD40L/CD154/TRAP, Rabbit (His)

  • UNSPSC Description: CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis[1]. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway[2][3]. CD40L also involves in B cell differentiation, maturation, and apoptosis[4]. CD40L in Rabbit, cleaved into a soluble form, acts as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Rabbit (His) has a total length of 149 amino acids (M113-L261), is expressed in E. coli cells with N-terminal 6*His-tag.
  • Type: Recombinant Proteins
  • Assay Protocol: https://www.medchemexpress.com/cytokines/cd40l-cd154-trap-protein-rabbit-his.html
  • Purity: 94.00
  • Smiles: MQKGDQDPQI AAHLISEASS KSSSVLQWAK KGYYTMSNTL VTLENGKQLK VKRQGFYYIY AQVTFCSNQE PSSQAPFIAS LCLKSSGGSE RILLRAANAR SSSKTCEQQS IHLGGVFELQ ADASVFVNVT DASQVNHGTG FTSFGLLKL
  • Molecular Weight: Approximately 20.2 kDa
  • References & Citations: [1]Blotta MH, et al. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol. 1996 May 1;156(9):3133-40.|[2]Schwabe RF, et al. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol. 2001 Jun 1;166(11):6812-9.|[3]Batlle A, et al. CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression. Mol Immunol. 2009 May;46(8-9):1727-35.|[4]Mikolajczak SA, et al. The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J Exp Med. 2004 Apr 5;199(7):1025-31.|[5]Takada YK, et al. Soluble CD40L activates soluble and cell-surface integrin αvβ3, α5β1, and α4β1 by binding to the allosteric ligand-binding site (site 2). J Biol Chem. 2021 Jan-Jun;296:100399.
  • Shipping Conditions: Blue Ice
  • Storage Conditions: Stored at -20°C for 2 years