Anti-Cytokeratin 18

Anti-Cytokeratin 18

• Description: Encoded by the KRT18 gene, the protein recognized by this antibody is the type I intermediate filament chain keratin 18. With Cytokeratin 8, Cytokeratin 18 is expressed in single layer epithelial tissues of the body and are involved in interleukin-6 (IL-6)-mediated barrier protection. When phosphorylated, Cytokeratin 18 also plays a role in filament reorganization. Diseases related to this gene include cryptogenic cirrhosis and non-alcoholic steatohepatitis. The Anti-Cytokeratin 18 Antibody does not react with stratified squamous epithelia but reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. This antibody is also useful in studies which involve differentiating cells of epithelial origin from hematopoietic cells.
• CAS Number: 9007-83-4
• Reactivity: Human
• Immunogen: PMC-42 Human Breast Carcinoma Cells
• Clonality: Monoclonal
• Type: Antibodies-Monoclonal
• Applications: IHC
• Concentration: 100µg/100µl
• Purity: The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
• Buffer: PBS, pH 7.4 with 0.05% sodium azide
• Shipping Conditions: Ice Pack
• Storage Conditions: This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
• Fragment: IgG1
• Specificity: Human Cytokeratin 18 polypeptide.
• Applications Notes: Use at an assay dependent concentration.