Anti-Androgen Receptor
CAT:
171-Y058080
Size:
100 μl
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Androgen Receptor
- Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
- CAS Number: 9007-83-4
- Reactivity: Human,Mouse
- Immunogen: Synthetic peptide conjugated to KLH
- Clonality: Polyclonal
- Type: Antibodies-Polyclonal
- Applications: WB,ELISA
- Concentration: 100ug/100ul
- Purity: Purified
- Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
- Shipping Conditions: Ice Pack
- Storage Conditions: This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
- Fragment: Rabbit IgG
- Specificity: Androgen Receptor antibody detects endogenous levels of Androgen Receptor protein. Not tested with other proteins
- Applications Notes: Recommended dilutions Peptide ELISA: 1:40,000 WB: 1/200 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user