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Recombinant Mouse IL33

CAT:
171-Z200155
Size:
10 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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Recombinant Mouse IL33

  • Description: IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines . In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment.
  • CAS Number: 9000-83-3
  • Gene Name: IL33
  • Gene Aliases: IL-33
    Recombinant Mouse Interleukin-33 (IL33)
  • Gene ID: 77125
  • Accession Number: Q8BVZ5
  • Organism: Mouse
  • Source: E. coli
  • Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method.
  • Purity: >95% as determined by SDS-PAGE
  • Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
  • Function: The ED(50) was determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.3 ng/mL.
  • Molecular Weight: 18
  • Shipping Conditions: Ambient Temperature
  • Storage Conditions: The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
  • Appearance: Lyophilized Powder
  • Formulation: Recombinant Interleukin-33 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.