(-)-Limonene

(-)-Limonene

• CAS Number: 5989-54-8
• UNSPSC Description: (-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture[1][2][3][4].
• Target Antigen: Antibiotic; Bacterial; CaMK
• Type: Natural Products
• Related Pathways: Anti-infection;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Infection; Metabolic Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/_S_-_-_-Limonene.html
• Purity: 95.0
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: CC1=CC[C@@H](C(C)=C)CC1
• Molecular Weight: 136.238
• References & Citations: [1]Larsen ST, et al. Effects of R-(+)- and S-(-)-limonene on the respiratory tract in mice. Hum Exp Toxicol. 2000 Aug;19(8):457-66.|[2]da Silva E G, et al. In vitro antimicrobial and antibiofilm activity of S-(-)-limonene and R-(+)-limonene against fish bacteria[J]. Fishes, 2021, 6(3): 32.|[3]Zhou W, et al. Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats. J Nutr Sci Vitaminol (Tokyo). 2009 Aug;55(4):367-73.|[4]Rhana P, et al. S-limonene protects the heart in an experimental model of myocardial infarction induced by isoproterenol: Possible involvement of mitochondrial reactive oxygen species. Eur J Pharmacol. 2022 Sep 5;930:175134.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched