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Flecainide (acetate)

CAT:
804-HY-17429-05
Size:
100 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Flecainide (acetate) - image 1

Flecainide (acetate)

  • CAS Number: 54143-56-5
  • UNSPSC Description: Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
  • Target Antigen: Sodium Channel
  • Type: Reference compound
  • Related Pathways: Membrane Transporter/Ion Channel
  • Applications: COVID-19-immunoregulation
  • Field of Research: Cardiovascular Disease
  • Assay Protocol: https://www.medchemexpress.com/flecainide-acetate.html
  • Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)
  • Smiles: O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.CC(O)=O
  • Molecular Weight: 474.39
  • References & Citations: [1]Yamashita T, Nakajima T, Hamada E,
 Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21.|[2]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34.|[3]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71.
  • Shipping Conditions: Room Temperature
  • Clinical Information: Launched