LV-320
CAT:
804-HY-112711-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LV-320
- CAS Number: 2449093-46-1
- UNSPSC Description: LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5?μM and a Kd of 16?μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo[1].
- Target Antigen: Atg4; Autophagy
- Type: Reference compound
- Related Pathways: Autophagy
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/LV-320.html
- Purity: 95.0
- Solubility: DMSO : 135 mg/mL (ultrasonic)
- Smiles: ClC1=CC2=NC=CC(/C=C/C3=CC=C(C(SCCC(O)=O)SCCC4=CC=CC=C4)C=C3)=C2C=C1
- Molecular Weight: 520.11
- References & Citations: [1]Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported