Umeclidinium (bromide)
CAT:
804-HY-12100-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Umeclidinium (bromide)
- Product Name Alternative: GSK573719A
- CAS Number: 869113-09-7
- UNSPSC Description: Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
- Target Antigen: mAChR
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Field of Research: Inflammation/Immunology; Cancer
- Assay Protocol: https://www.medchemexpress.com/Umeclidinium-bromide.html
- Purity: 99.72
- Solubility: DMSO : ≥ 25 mg/mL
- Smiles: OC(C12CC[N+](CC2)(CCOCC3=CC=CC=C3)CC1)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]
- Molecular Weight: 508.49
- References & Citations: [1]Salmon M, et al. Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70.|[2]Cazzola M, et al. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev. 2012 Jul;64(3):450-504.|[3]Calzetta L, et al. Pharmacological characterization of the interaction between umeclidinium and vilanterol in human bronchi. Eur J Pharmacol. 2017 Jul 14. pii: S0014-2999(17)30470-3.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched