GTS-21

GTS-21

• CAS Number: 148372-04-7
• UNSPSC Description: GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. GTS-21 can be used in age-associated memory impairment (AAMI) and Alzheimer's disease research[1][2][3].
• Target Antigen: 5-HT Receptor; nAChR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/gts-21.html
• Smiles: COC(C=C(C=C1)OC)=C1/C=C2C(C3=CN=CC=C3)=NCCC/2
• Molecular Weight: 308.37
• References & Citations: [1]Briggs CA, et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997;57(1-2):231-241.|[2]Zhang R, et al. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. J Pharmacol Exp Ther. 2006;317(3):1276-1284.|[3]Mei Z, et al. α7 nAchR agonist GTS 21 reduces radiation induced lung injury. Oncol Rep. 2018;40(4):2287-2297.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 2