Nur77 modulator 3
CAT:
804-HY-162147-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nur77 modulator 3
- CAS Number: 2097787-75-0
- UNSPSC Description: Nur77 modulator 3 (9e) can bind to Nur77 and inhibit TGF-β1-induced α-SMA and COLA1 expression in a Nur77-dependent manner. Nur77 modulator 3 induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis[1].
- Target Antigen: Autophagy; mTOR
- Type: Reference compound
- Related Pathways: Autophagy;PI3K/Akt/mTOR
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nur77-modulator-3.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: S=C(N/N=C/C1=CNC2=CC=CC=C12)NC3=CC=C(C)C=C3
- Molecular Weight: 308.40
- References & Citations: [1]Lin G, et al. Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents. Bioorg Chem. 2023 Dec 16;143:107022.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported