5β,6β-epoxycholestanol

5β,6β-epoxycholestanol

• Product Name Alternative: Cholesterol 5beta,6beta-epoxide
• CAS Number: 4025-59-6
• UNSPSC Description: 5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue[1][2][3].
• Target Antigen: Biochemical Assay Reagents
• Type: Biochemical Assay Reagents
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/cholesterol-5beta-6beta-epoxide.html
• Purity: 99.0
• Solubility: Ethanol : 20 mg/mL (ultrasonic;warming)
• Smiles: C[C@]12[C@@]3(C[C@H](CC2)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@H](C)CCCC(C)C)C)([H])O3
• Molecular Weight: 402.65
• References & Citations: [1]Pulfer M K, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant[J]. Journal of Biological Chemistry, 2004, 279(25): 26331-26338.|[2]Aringer L, et al. Formation and metabolism in vitro of 5, 6-epoxides of cholesterol and 尾-sitosterol[J]. Journal of Lipid Research, 1974, 15(4): 389-398.|[3]Garcia-Cruset S, et al. Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions. Free Radic Res. 2001 Jul;35(1):31-41.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported