Conantokin G (TFA)

Conantokin G (TFA)

• UNSPSC Description: Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G TFA has neuroprotective properties[1][2].
• Target Antigen: iGluR
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/conantokin-g-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C(F)(F)F)=O.NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
• Molecular Weight: 2378.21
• References & Citations: [1]S D Donevan, et al. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol. 2000 Sep;58(3):614-23.|[2]A J Williams, et al. Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther. 2000 Jul;294(1):378-86.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported