N3-C4-NHS ester
CAT:
804-HY-126522-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
N3-C4-NHS ester
- CAS Number: 478801-48-8
- UNSPSC Description: N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Target Antigen: ADC Linker
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/n3-c4-nhs-ester.html
- Purity: 99.34
- Solubility: 10 mM in DMSO
- Smiles: O=C(ON1C(CCC1=O)=O)CCCCN=[N+]=[N-]
- Molecular Weight: 240.22
- References & Citations: [1]Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported