PTP1B Mouse Monoclonal Antibody [D0-C7]

PTP1B Mouse Monoclonal Antibody [D0-C7]

• Description: The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. On the basis of sequence analysis, PTP1B (PTPase 1B) expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, a homolog of the neural adhesion molecule (NCAM). PTP1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.
• Product Name Alternative: PTP1B antibody Non receptor tyrosine phosphatase 1 antibody Protein phosphotyrosylphosphatase 1B antibody Protein tyrosine phosphatase 1B antibody Protein tyrosine phosphatase non receptor type 1 antibody Protein tyrosine phosphatase placental antibody Protein-tyrosine phosphatase 1B antibody PTN1_HUMAN antibody PTP 1B antibody PTP-1B antibody PTPN 1 antibody PTPN1 antibody Tyrosine protein phosphatase non receptor type 1 antibody Tyrosine-protein phosphatase non-receptor type 1 antibody
• Abbreviation: PTP-1B, PTPN1, PTP1B
• CAS Number: 9007-83-4
• Swiss Prot: P18031 Human, P35821 Mouse, P20417 Rat
• Cellular Locus: Endoplasmic reticulum membrane
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human PTP1B aa 1-250.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: A431 cell lysate, Hela cell lysate, A549 cell lysate, HepG2 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, C6 cell lysate, Hela, A549, HepG2, Jurkat.
• Concentration: 2 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:100-1:500 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 50 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No