Annexin A1 Rabbit Polyclonal Antibody

Annexin A1 Rabbit Polyclonal Antibody

• Description: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca2+ and can bind up to eight Ca2+ ions. Displays Ca2+-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton.
• Product Name Alternative: Annexin 1 antibody Annexin A1 antibody Annexin I (lipocortin I) antibody Annexin I antibody Annexin-1 antibody AnnexinA1 antibody AnnexinI antibody ANX 1 antibody ANX A1 antibody ANX1 antibody ANXA 1 antibody ANXA1 antibody ANXA1 protein antibody ANXA1_HUMAN antibody Calpactin 2 antibody Calpactin II antibody Calpactin-2 antibody CalpactinII antibody Chromobindin 9 antibody Chromobindin-9 antibody Chromobindin9 antibody HGNC:533 antibody Lipocortin 1 antibody Lipocortin I antibody Lipocortin1 antibody LipocortinI antibody LPC 1 antibody LPC1 antibody p35 antibody Phospholipase A2 inhibitory protein antibody
• Abbreviation: Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANXA1, ANX1, LPC1
• CAS Number: 9007-83-4
• Swiss Prot: P04083 Human, P10107 Mouse, P07150 Rat
• Cellular Locus: Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Annexin A1 aa 150-310.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: A431 cell lysate, K-562 cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, A431, NIH/3T3, C6, human esophagus tissue, human placenta tissue, mouse esophagus tissue, rat esophagus tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell:1:100-1:250 ;IHC-P:1:200-1:1,000 ;FC: 1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 39 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No