L-Cycloserine
CAT:
804-HY-B1122-02
Size:
10 mM / 1 mL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-Cycloserine
- CAS Number: 339-72-0
- UNSPSC Description: L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].
- Target Antigen: GABA Receptor; HIV
- Type: Natural Products
- Related Pathways: Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Neurological Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/L-Cycloserine.html
- Purity: 99.50
- Solubility: DMSO : 12.5 mg/mL (ultrasonic)|H2O : 13.33 mg/mL (ultrasonic)
- Smiles: O=C1NOC[C@@H]1N
- Molecular Weight: 102.093
- References & Citations: [1]Tathyana Mar Amorim Franco, et al. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017 May 19;12(5):1235-1244.|[2]S H Chung, et al. L-cycloserine: a potent anticonvulsant. Epilepsia. 1984 Jun;25(3):353-62.|[3]P Polc, et al. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25(4):411-8.|[4]K S Sundaram, et al. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine. J Lipid Res. 1985 Apr;26(4):473-7.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Launched