EZH2-IN-17
CAT:
804-HY-149726-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EZH2-IN-17
- CAS Number: 2489672-09-3
- UNSPSC Description: EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].
- Target Antigen: Histone Methyltransferase
- Type: Reference compound
- Related Pathways: Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ezh2-in-17.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1C(CNC(C2=CC(C3=CC=C(C(N4CCOCC4)CC5)C5=C3)=CC(N(C6CCOCC6)CC)=C2C)=O)=C(C)C=C(C)N1
- Molecular Weight: 598.77
- References & Citations: [1]Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported