Pyridoxal 5'-​phosphate (monohydrate)

Pyridoxal 5'-​phosphate (monohydrate)

• CAS Number: 41468-25-1
• UNSPSC Description: Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP)[1][2].
• Target Antigen: Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/pyridoxal-5-phosphate-monohydrate.html
• Purity: 99.38
• Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 6.25 mg/mL (ultrasonic)
• Smiles: O=CC1=C(O)C(C)=NC=C1COP(O)(O)=O.[H]O[H]
• Molecular Weight: 265.16
• References & Citations: [1]Allen GF, et al. Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.J Neurochem. 2010 Jul;114(1):87-96.|[2]Calderón-Ospina CA, et al. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.CNS Neurosci Ther. 2020 Jan;26(1):5-13.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched