CB10-277

CAT:

804-HY-126160

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CAS Number: 7203-91-0
UNSPSC Description: CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma[1].
Target Antigen: DNA Alkylator/Crosslinker; Nucleoside Antimetabolite/Analog
Type: Reference compound
Related Pathways: Cell Cycle/DNA Damage
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/cb10-277.html
Smiles: O=C(C1=CC=C(C=C1)/N=N/N(C)C)O
Molecular Weight: 193.20
References & Citations: [1]Siow Ming, et al. "In vivo depletion of O 6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue." Cancer chemotherapy and pharmacology 31 (1992): 240-246.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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