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Iodophenpropit (dihydrobromide)

CAT:
804-HY-107568-02
Size:
5 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Iodophenpropit (dihydrobromide) - image 1

Iodophenpropit (dihydrobromide)

  • CAS Number: 145196-87-8
  • UNSPSC Description: Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1].
  • Target Antigen: Histamine Receptor
  • Type: Reference compound
  • Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
  • Applications: COVID-19-immunoregulation
  • Field of Research: Inflammation/Immunology
  • Assay Protocol: https://www.medchemexpress.com/iodophenpropit-dihydrobromide.html
  • Purity: 99.70
  • Solubility: DMSO : 57.6 mg/mL (ultrasonic;warming)
  • Smiles: N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br
  • Molecular Weight: 576.13
  • References & Citations: [1]Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [125I]Iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur J Pharmacol. 1992 Jul 7;217(2-3):203-5.|[2]Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21.|[3]Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8.|[4]Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.
  • Shipping Conditions: Blue Ice
  • Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
  • Clinical Information: No Development Reported