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Quetiapine-d4-1 (fumarate)

CAT:
804-HY-B0031S5
Size:
1 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Quetiapine-d4-1 (fumarate) - image 1

Quetiapine-d4-1 (fumarate)

  • CAS Number: 2820085-77-4
  • UNSPSC Description: Quetiapine-d4-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].
  • Target Antigen: 5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds
  • Type: Isotope-Labeled Compounds
  • Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
  • Applications: Neuroscience-Neuromodulation
  • Field of Research: Neurological Disease
  • Solubility: 10 mM in DMSO
  • Smiles: OC([2H])([2H])C([2H])([2H])OCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=C2C=CC=C4.O=C(O)/C=C/C(O)=O.[0.5]
  • Molecular Weight: 445.57
  • References & Citations: [1]Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.|[2]Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported