Proadrenomedullin (N-20) (bovine, porcine)
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804-HY-P5876
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Proadrenomedullin (N-20) (bovine, porcine)
- UNSPSC Description: Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a potent and noncompetitive hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Proadrenomedullin (N-20) (bovine, porcine) inhibits catecholamine secretion with an IC50 of 350 nM in PC12 pheochromocytoma cells. Proadrenomedullin (N-20) (bovine, porcine) also blocks (EC50≈270 nM) nicotinic cholinergic agonist desensitization of catecholamine release, as well as desensitization of nicotinic signal transduction (22Na+ uptake)[1].
- Target Antigen: nAChR
- Type: Peptides
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/proadrenomedullin-n-20-bovine-porcine.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
- Molecular Weight: 2444.84
- References & Citations: [1]Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported