Cefaclor

Cefaclor

• CAS Number: 53994-73-3
• UNSPSC Description: Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].
• Target Antigen: 5-HT Receptor; Antibiotic; Bacterial; Penicillin-binding protein (PBP)
• Type: Reference compound
• Related Pathways: Anti-infection;GPCR/G Protein;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Cefaclor.html
• Purity: 99.61
• Solubility: DMSO : 18.5 mg/mL (ultrasonic;warming)|H2O : 3.85 mg/mL (ultrasonic)
• Smiles: O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O
• Molecular Weight: 367.81
• References & Citations: [1]Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13(1):15529. |[2]Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. |[3]Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55(6):1473-83. |[4]Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched