Necrostatin-1

Necrostatin-1

• CAS Number: 4311-88-0
• UNSPSC Description: Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor[1].
• Target Antigen: Autophagy; Ferroptosis; Indoleamine 2,3-Dioxygenase (IDO); RIP kinase
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Necrostatin-1.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
• Molecular Weight: 259.334
• References & Citations: [1]Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9.|[2]Linkermann A, et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013 Oct;24(10):1545-57.|[3]Huang C, et al. Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS One. 2013 Jun 28;8(6):e66326.|[4]Feyen D, et al. Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function. Cardiovasc Res. 2013 Jul 1;99(1):83-91.|[5]Zhou K, et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported