Anti-NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/3347)

Anti-NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/3347)

• Description: NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: NK3 Homeobox 1; Homeobox Protein NK-3 Homolog A; NKX3-1; NKX3A; NK3 Transcription Factor Related; Locus 1 (Drosophila); NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila); Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX3
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: NKX3-1
• Gene ID: 4824
• NCBI Gene ID: 55999
• UniProt: Q99801
• Cellular Locus: Nucleus
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinantfragment(around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)
• Target Antigen: NKX3.1
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Clone: NKX3.1/3347
• Conjugation: Purified, with BSA
• Disease: Tumor
• Source: Animal
• Applications: IHC, FFPE (verified)
• Validated Applications: IHC, FFPE
• Positive Control: Highly expressed in the prostate and at a lower level in the testis.
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Molecular Weight: 35 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years