Anti-CD74 (B-Cell Marker)(CLIP/3127R)

Anti-CD74 (B-Cell Marker)(CLIP/3127R)

• Description: Recognizes a protein of ~35 kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma ( ). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: CLIP; DHLAG; Gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLADR-gamma (HLADG); Ia antigen-associated invariant chain; la-gamma; Major histocompatibility complex class II invariant chain; MHC HLA-DR gamma chain
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: CD74
• Gene ID: 972
• NCBI Gene ID: 436568
• UniProt: P044233
• Cellular Locus: Endoplasmic reticulum|Nucleus|Vesicular
• Host: Rabbit
• Species Reactivity: Baboon, Human, Mouse
• Immunogen: SU-DHL-4 lymphoma cells
• Target Antigen: CD74
• Clonality: Recombinant Monoclonal
• Isotype: IgG
• Clone: CLIP/3127R
• Conjugation: Purified, with BSA
• Disease: Tumor
• Source: Animal
• Applications: Flow (verified) | IHC, FFPE (verified) | WB (verified)
• Validated Applications: FC, IHC, FFPE, WB
• Positive Control: 293T, Daudi or Raji cells. Tonsil or lymph node.
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Molecular Weight: 33-41 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years