Anti-CD4, Mouse (T-Cell Marker)(GK1.5)

Anti-CD4, Mouse (T-Cell Marker)(GK1.5)

• Description: CD4 is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase, lck. CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: CD4 (L3T4); CD4; CD4 Lymphocyte deficiency; included; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene ID: 12504
• NCBI Gene ID: 2209
• UniProt: P06332
• Cellular Locus: Plasma membrane
• Host: Rat
• Species Reactivity: Mouse
• Immunogen: Mouse CTL clone V4
• Target Antigen: CD4
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Clone: GK1.5
• Conjugation: Purified, BSA-free
• Disease: Tumor
• Source: Animal
• Applications: Flow, surface (published) | Functional studies (published)
• Validated Applications: FC, Functional assays
• Positive Control: Spleen, Thymus or Lymph Node.
• Concentration: 1 mg/mL
• Buffer: PBS, no BSA, no azide
• Molecular Weight: 55 kDa
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Immunological Rev (1982) 74:29-56. (functional studies) J Immunol (2005) 175: 2357-2365. (Flow)
• Shipping Conditions: Room temperature
• Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years