D-Mannitol

D-Mannitol

• CAS Number: 69-65-8
• UNSPSC Description: D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].
• Target Antigen: Adrenergic Receptor; Apoptosis; Endogenous Metabolite; PGC-1α; PKA
• Type: Natural Products
• Related Pathways: Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt;TGF-beta/Smad
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/D-Mannitol.html
• Purity: 99.93
• Solubility: H2O : ≥ 36 mg/mL
• Smiles: OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
• Molecular Weight: 182.17
• References & Citations: [1]Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.|[2]Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.|[3]Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.|[4] Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29(1):325-331.|[5]Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77(4):584-589.|[6]Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28(7):1437-1444.|[7]Jeon HJ, et al. D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism. Cells. 2021;10(4):768. Published 2021 Mar 31.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched