AZD8330

AZD8330

• Product Name Alternative: ARRY-424704; ARRY-704
• CAS Number: 869357-68-6
• UNSPSC Description: AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.
• Target Antigen: MEK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/AZD8330.html
• Purity: 99.14
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: IC1=CC(F)=C(C=C1)NC(N2C)=C(C=C(C2=O)C)C(NOCCO)=O
• Molecular Weight: 461.23
• References & Citations: [1]Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9.|[2]Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 1