Doripenem

Doripenem

• CAS Number: 148016-81-3
• UNSPSC Description: Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/doripenem.html
• Purity: 99.91
• Solubility: DMSO : ≥ 200 mg/mL
• Smiles: O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
• Molecular Weight: 420.50
• References & Citations: [1]Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.|[2]Aryun Kim, et al. In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures. Antimicrob Agents Chemother. 2008 Jul;52(7):2497-502.Antimicrob Agents Chemother. 2023 May 18;e0160322.|Biomed Res Int. 2018 Jul 2;2018:3579832. |Microbiol Spectr. 2022 Dec 8;e0303822.|Microbiol Spectr. 2023 Apr 24;e0069223.|Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00282-18.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: Launched