β-Tocopherol-d3

β-Tocopherol-d3

• CAS Number: 936230-75-0
• UNSPSC Description: β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].
• Target Antigen: Isotope-Labeled Compounds; Tyrosinase
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Solubility: 10 mM in DMSO
• Smiles: CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C([2H])([2H])[2H])C(O)=C1
• Molecular Weight: 419.70
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Azzi A, et, al. d-alpha-tocopherol control of cell proliferation. Mol Aspects Med. 1993; 14(3): 265-71.|[3]Tasinato A, et, al. d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26): 12190-4.|[4]Kamei Y, et, al. Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. Cytotechnology. 2009 Apr; 59(3): 183-90.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported