Gepotidacin (mesylate hydrate)

Gepotidacin (mesylate hydrate)

• CAS Number: 1624306-20-2
• UNSPSC Description: Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase[1][2].
• Target Antigen: Antibiotic; Bacterial; Topoisomerase
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/gepotidacin-mesylate-hydrate.html
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC5=CC(CCCO6)=C6C=N5)CC4)CN2C1=O.CS(=O)(O)=O.O.O
• Molecular Weight: 580.65
• References & Citations: [1]Gibson EG, et al. Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. ACS Infect Dis. 2019 Apr 12;5(4):570-581. |[2]Watkins RR, et al. Gepotidacin: a novel, oral, 'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea. J Antimicrob Chemother. 2023 May 3;78(5):1137-1142.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 3