Citalopram

Citalopram

• CAS Number: 59729-33-8
• UNSPSC Description: Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission[1][2][3].
• Target Antigen: Serotonin Transporter
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/citalopram.html
• Purity: 99.87
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N#CC1=CC=C2C(CCCN(C)C)(OCC2=C1)C3=CC=C(C=C3)F
• Molecular Weight: 324.399
• References & Citations: [1]Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76. |[2]Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477. |[3]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.|[4]Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631.Comput Struct Biotechnol J. 2023 Jul 7, 21, 3490-3502.|Orebro University. 2024.|Eur J Pharmacol. 2018 Sep 27;841:57-66.|J Clin Psychopharmacol. 2021 Jun 11.|Neurochem Int. 2019 Dec;131:104552.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Research Square Preprint. 2021 Feb.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched