CC-115
CAT:
804-HY-16962-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CC-115
- CAS Number: 1228013-15-7
- UNSPSC Description: CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
- Target Antigen: DNA-PK; mTOR
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/CC-115.html
- Solubility: DMSO : 20 mg/mL (ultrasonic)
- Smiles: O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
- Molecular Weight: 336.35
- References & Citations: [1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19.|Front Pharmacol. 2020 Nov 11;11:580407.
- Shipping Conditions: Room Temperature
- Clinical Information: Phase 1