Cimifugin (Standard)

Cimifugin (Standard)

• CAS Number: 37921-38-3
• UNSPSC Description: Cimifugin (Standard) is the analytical standard of Cimifugin. This product is intended for research and analytical applications. Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions[1]. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS[2].
• Target Antigen: NF-κB
• Type: Reference Standards
• Related Pathways: NF-κB
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cimifugin-standard.html
• Smiles: O=C1C=C(CO)OC2=CC(O[C@H](C(C)(O)C)C3)=C3C(OC)=C12
• Molecular Weight: 306.31
• References & Citations: [1]Xiaoyu Wang, et al. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. J Cell Mol Med. 2017 Nov;21(11):2926-2936.|[2]Han B, Dai Y, Wu H, et al. Cimifugin Inhibits Inflammatory Responses of RAW264.7 Cells Induced by Lipopolysaccharide. Med Sci Monit. 2019;25:409-417.|[3]Duan J, Hu X, Li T, Wu G, Dou P, Ouyang Z. Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis. Front Pharmacol. 2021;12:724256.
• Shipping Conditions: Room temperature