VBIT-3
CAT:
804-HY-135571
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
VBIT-3
- CAS Number: 2088463-66-3
- UNSPSC Description: VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].
- Target Antigen: VDAC
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/vbit-3.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C(N1CCN(C2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O
- Molecular Weight: 453.84
- References & Citations: [1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported