(S)-Timolol (maleate)

(S)-Timolol (maleate)

• CAS Number: 26921-17-5
• UNSPSC Description: (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3].
• Target Antigen: Adrenergic Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/s-timolol-maleate.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C.O=C(O)/C=C\C(O)=O
• Molecular Weight: 432.49
• References & Citations: [1]Mitrović M, et al. Analytical quality by design development of an ecologically acceptable enantioselective HPLC method for timolol maleate enantiomeric purity testing on ovomucoid chiral stationary phase. J Pharm Biomed Anal. 2020 Feb 20;180:113034.|[2]Wedian F, et al. Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride. Acta Pharm. 2020 Sep 1;70(3):373-385.|[3]Sun L, et al. Fractional 2940-nm Er:YAG Laser-Assisted Drug Delivery of Timolol Maleate for the Treatment of Deep Infantile Hemangioma. J Dermatolog Treat. 2020 Feb 11:1-24.Protein Cell. 2019 Mar;10(3):178-195.|Patent. US20230090708A1.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched