EGFR/ACK1-IN-1
CAT:
804-HY-162254-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR/ACK1-IN-1
- UNSPSC Description: EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity[1].
- Target Antigen: Ack1; EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-t790m-l858r-ack1-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: ClC1=CC=C(C2=C1)N=C(N=C2NC3=CC=CC(NC(C=C)=O)=C3)NC4=CN(N=C4)CC
- Molecular Weight: 433.89
- References & Citations: [1]Wang A, et al. Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. J Med Chem. 2024 Feb 22;67(4):2777-2801.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported