BOLD-100 (free base)
CAT:
804-HY-147039-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BOLD-100 (free base)
- CAS Number: 783324-98-1
- UNSPSC Description: BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
- Target Antigen: Autophagy; HSP
- Type: Reference compound
- Related Pathways: Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/bold-100-free-base.html
- Solubility: 10 mM in DMSO
- Smiles: [Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
- Molecular Weight: 479.15
- References & Citations: [1]Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2